Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Issue 3, Volume 12, 2024
Issue 2, Volume 12, 2024
Issue 1, Volume 12, 2024
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Issue 12, Volume 11, 2023
Issue 11, Volume 11, 2023
Issue 10, Volume 11, 2023
Issue 9, Volume 11, 2023
Issue 8, Volume 11, 2023
Issue 7, Volume 11, 2023
Issue 6, Volume 11, 2023
Issue 5, Volume 11, 2023
Issue 4, Volume 11, 2023
Issue 3, Volume 11, 2023
Issue 2, Volume 11, 2023
Issue 1, Volume 11, 2023
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Issue 12, Volume 10, 2022
Issue 11, Volume 10, 2022
Issue 10, Volume 10, 2022
Issue 9, Volume 10, 2022
Issue 8, Volume 10, 2022
Issue 7, Volume 10, 2022
Issue 6, Volume 10, 2022
Issue 5, Volume 10, 2022
Issue 4, Volume 10, 2022
Issue 3, Volume 10, 2022
Issue 2, Volume 10, 2022
Issue 1, Volume 10, 2022
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Issue 12, Volume 9, 2021
Issue 11, Volume 9, 2021
Issue 10, Volume 9, 2021
Issue 9, Volume 9, 2021
Issue 8, Volume 9, 2021
Issue 7, Volume 9, 2021
Issue 6, Volume 9, 2021
Issue 5, Volume 9, 2021
Issue 4, Volume 9, 2021
Issue 3, Volume 9, 2021
Issue 2, Volume 9, 2021
Issue 1, Volume 9, 2021
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Issue 12, Volume 8, 2020
Issue 11, Volume 8, 2020
Issue 10, Volume 8, 2020
Issue 9, Volume 8, 2020
Issue 8, Volume 8, 2020
Issue 7, Volume 8, 2020
Issue 6, Volume 8, 2020
Issue 5, Volume 8, 2020
Issue 4, Volume 8, 2020
Issue 3, Volume 8, 2020
Issue 2, Volume 8, 2020
Issue 1, Volume 8, 2020
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Issue 12, Volume 7, 2019
Issue 11, Volume 7, 2019
Issue 10, Volume 7, 2019
Issue 9, Volume 7, 2019
Issue 8, Volume 7, 2019
Issue 7, Volume 7, 2019
Issue 6, Volume 7, 2019
Issue 5, Volume 7, 2019
Issue 4, Volume 7, 2019
Issue 3, Volume 7, 2019
Issue 2, Volume 7, 2019
Issue 1, Volume 7, 2019
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Issue 12, Volume 6, 2018
Issue 11, Volume 6, 2018
Issue 10, Volume 6, 2018
Issue 9, Volume 6, 2018
Issue 8, Volume 6, 2018
Issue 7, Volume 6, 2018
Issue 6, Volume 6, 2018
Issue 5, Volume 6, 2018
Issue 4, Volume 6, 2018
Issue 3, Volume 6, 2018
Issue 2, Volume 6, 2018
Issue 1, Volume 6, 2018
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Issue 12, Volume 5, 2017
Issue 11, Volume 5, 2017
Issue 10, Volume 5, 2017
Issue 9, Volume 5, 2017
Issue 8, Volume 5, 2017
Issue 7, Volume 5, 2017
Issue 6, Volume 5, 2017
Issue 5, Volume 5, 2017
Issue 4, Volume 5, 2017
Issue 3, Volume 5, 2017
Issue 2, Volume 5, 2017
Issue 1, Volume 5, 2017
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Issue 12, Volume 4, 2016
Issue 11, Volume 4, 2016
Issue 10, Volume 4, 2016
Issue 9, Volume 4, 2016
Issue 8, Volume 4, 2016
Issue 7, Volume 4, 2016
Issue 6, Volume 4, 2016
Issue 5, Volume 4, 2016
Issue 4, Volume 4, 2016
Issue 3, Volume 4, 2016
Issue 2, Volume 4, 2016
Issue 1, Volume 4, 2016
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Issue 12, Volume 3, 2015
Issue 11, Volume 3, 2015
Issue 10, Volume 3, 2015
Issue 9, Volume 3, 2015
Issue 8, Volume 3, 2015
Issue 7, Volume 3, 2015
Issue 6, Volume 3, 2015
Issue 5, Volume 3, 2015
Issue 4, Volume 3, 2015
Issue 3, Volume 3, 2015
Issue 2, Volume 3, 2015
Issue 1, Volume 3, 2015
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Issue 12, Volume 2, 2014
Issue 11, Volume 2, 2014
Issue 10, Volume 2, 2014
Issue 9, Volume 2, 2014
Issue 8, Volume 2, 2014
Issue 7, Volume 2, 2014
Issue 6, Volume 2, 2014
Issue 5, Volume 2, 2014
Issue 4, Volume 2, 2014
Issue 3, Volume 2, 2014
Issue 2, Volume 2, 2014
Issue 1, Volume 2, 2014
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
Issue 1, Volume 1, 2013
American Journal of Medical Case Reports. 2022, 10(12), 304-306
DOI: 10.12691/AJMCR-10-12-2
Case Report

Intrathecal Morphine-induced Hypothermia after Caesarean Delivery and Reversal with a Short Acting Benzodiazepine

Reginald Caldecott1,

1Department of Anaesthesia, Portiuncula University Hospital, Ballinasloe, Ireland

Pub. Date: December 04, 2022

Cite this paper

Reginald Caldecott. Intrathecal Morphine-induced Hypothermia after Caesarean Delivery and Reversal with a Short Acting Benzodiazepine. American Journal of Medical Case Reports. 2022; 10(12):304-306. doi: 10.12691/AJMCR-10-12-2

Abstract

This case report describes a patient with hypothermia induced via spinal morphine and its reversal with Lorazepam, a short acting benzodiazepine. The patient presented with refractory hypothermia following Caesarean section with paradoxical vasodilation and diaphoresis. The successful prompt reversal of the hypothermia with Lorazepam while maintaining pain relief highlights the benefit of its use in cases of morphine-induced hypothermia. However large clinical trials are still needed to verify the benefits of such treatment.

Keywords

Morphine-induced hypothermia, Benzodiazipine, Lorazepam, spinal anaesthesia, Obstetric anaesthesia , cesarean delivery , medication adverse effect

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Peck T, Harris B. Pharmacology for anaesthesia and intensive care. 5th ed. Cambridge University Press; 2021.
 
[2]  Gropper M, Miller R, Eriksson L, Fleisher L, Wiener-Kronish J, Cohen N et al. Miller's Anesthesia, Volume 2. 7th ed. Philadelphia, PA: Churchill Livingstone; 2009.
 
[3]  Clark W. Influence of opioids on central thermoregulatory mechanisms. Pharmacology Biochemistry and Behavior. 1979; 10(4): 609-613.
 
[4]  Roth J. Hypothermia During Cesarean Delivery. Anesthesia & amp; Analgesia. 2018; 126(6): 2151-2152.
 
[5]  Ozaki M, Kurz A, Sessler D, Lenhardt R, Schroeder M, Moayeri A et al. Thermoregulatory Thresholds during Epidural and Spinal Anesthesia. Anesthesiology. 1994; 81(2): 282-288.
 
[6]  Su C, Liu M, Lin M. Intraventricular morphine produces pain relief, hypothermia, hyperglycaemia and increased prolactin and growth hormone levels in patients with cancer pain. Journal of Neurology. 1987; 235(2): 105-108.
 
[7]  Del Rio-Garcia J, Cremades A. GABAergic mechamisms in morphine-induced hypothermia. European Journal of Pharmacology. 1990; 187(3): 495-500.
 
[8]  Cavicchini E, Candeletti S, Spampinato S, Ferri S. Hypothermia elicited by some prodynorphin-derived peptides: Opioid and non-opioid actions. Neuropeptides. 1989; 14(1): 45-50.
 
[9]  Mach J, Van Havel T, Gadwood J, Biegner MA. Intrathecal Opioid-Induced Hypothermia Following Subarachnoid Block With Morphine Injection for Elective Cesarean Delivery: A Case Report. AANA J. 2016 Feb; 84(1): 23-6.
 
[10]  Hess P, Snowman C, Wang J. Hypothermia after cesarean delivery and its reversal with lorazepam. International Journal of Obstetric Anesthesia. 2005; 14(4): 279-283.