Cytogenetic Remission in Response to Dasatinib Monotherapy in Mixed-phenotype Acute Leukemia with t(9;22)(q34.1;q11.2) Translocation

Motoharu Shibusawa^1,

¹IMS group, Shinmatsudo Central General Hospital, Department of Hematology, Chiba, Japan

Cite this paper

Motoharu Shibusawa. Cytogenetic Remission in Response to Dasatinib Monotherapy in Mixed-phenotype Acute Leukemia with t(9;22)(q34.1;q11.2) Translocation. American Journal of Medical Case Reports. 2022; 10(7):181-184. doi: 10.12691/AJMCR-10-7-5

Abstract

The case of a 44-year-old Japanese woman diagnosed with mixed-phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 (MPAL-BA) is reported. Her white blood cell count was 5,100/μL with 13.0% blasts; positive for CD34, HLA-DR, MPO, CD33, CD19, cytoplasmic (cy) CD79a, CD22, CD10, and TdT; and negative for cyCD3. G-band cytogenetic analysis detected a normal karyotype. Fluorescence in situ hybridization detected BCR-ABL1 (9.0%) and a minor BCR-ABL1 mRNA at 4.2 × 10⁴ copies/µg RNA. The patient was treated with dasatinib monotherapy (140 mg daily). Bone marrow examination revealed cytogenetic remission (CyCR) with minor BCR-ABL1 mRNA detected at 1.1 × 10³ copies /µg RNA on day 31. No adverse events of dasatinib therapy were observed. MPAL-BA is very rare and dasatinib monotherapy efficacy for this diagnosis was previously unknown. The patient achieved CyCR with dasatinib monotherapy as first-line treatment. The present case suggests that dasatinib monotherapy may be effective and safe for MPAL-BA induction therapy.

Keywords

mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2), BCR-ABL1 translocation, mixed phenotype acute leukemia, BCR-ABL1, dasatinib

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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