Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2022, 10(8), 210-213
DOI: 10.12691/AJMCR-10-8-9
Case Report

Atypical Fibroxanthoma in Young Omani Teenager a Rare Presentation Case Report and Literature Review

Sheikhan Al Hashmi1, Amina Al-Yaqoobi1, , Hunaina Alkindi2, Mina George2 and Zahra Alabri2

1Plastic surgery and reconstruction surgery, Khoula Hospital, Muscat, Oman

2Histopathology Department, Khoula Hospital, Muscat, Oman

Pub. Date: August 23, 2022

Cite this paper

Sheikhan Al Hashmi, Amina Al-Yaqoobi, Hunaina Alkindi, Mina George and Zahra Alabri. Atypical Fibroxanthoma in Young Omani Teenager a Rare Presentation Case Report and Literature Review. American Journal of Medical Case Reports. 2022; 10(8):210-213. doi: 10.12691/AJMCR-10-8-9

Abstract

Cutaneous Atypical fibroxanthoma (AFX) typically occurs on the head and neck of sun-damaged areas in older Caucasians & it's a diagnosis by exclusion of other malignant neoplasms with similar histopathology or morphology. In this case report and literature review, we report a much less common presentation as the first case to our knowledge of AFX on a teenage female with darker skin, this lesion on the dominant hand that needed re-excision in order to get a clear margin. A high index of suspicion of this less common type in a younger patient presenting with a cutaneous nodule is to be kept in mind to minimize the number of excisions and increase patient's satisfaction.

Keywords

Atypical fibroxanthoma, Skin neoplasms, young patient

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Fretzin EB, Helwig EB. Atypical fibroxanthoma of the skin. A clinicopathologic study of 140 cases. Cancer. 1973; 31: 1541-52.
 
[2]  M. Koch, A.J. Freundl, A. Agaimy, F. Kiesewetter, J. Künzel, I. Cicha, et al. Atypical fibroxanthoma - histological diagnosis, immunohistochemical markers and concepts of therapy, Anticancer Res, 35 (2015), pp. 5717-5735.
 
[3]  E. Ferri, G.A. Iaderosa, E. Armato, Atypical fibroxanthoma of the external ear in a cardiac transplant recipient: case report and the causal role of the immunosuppressive therapy Auris Nasus Larynx, 35 (2008), pp. 260-263.
 
[4]  Melendez MM, Xu X, McClain SA, Huang SI. Atypical fibroxanthoma in a young woman: An unusual case presentation. Can J Plast Surg. 2007; 15(3): 169-172.
 
[5]  Sze-Wen Ting, Shih-Jyun Yang, Yung-Yi Lee, Atypical fibroxanthoma in a young female patient with systemic lupus erythematosus: A case report and literature review, Dermatologica Sinica, Volume 36, Issue 4, 2018, Pages 214-217, ISSN 1027-8117.
 
[6]  Dei Tos AP, Maestro R, Doglioni C, et al. Ultraviolet-induced p53 mutations in atypical fibroxanthoma. Am J Pathol. 1994; 145(1): 11-17.
 
[7]  Pujani M, Hassan MJ, Jetley S. Atypical fibroxanthoma in a young female misdiagnosed clinically as a malignant melanoma- An unusual presentation. J Can Res Ther [serial online] 2015 [cited 2021 Jun 18]; 11: 1027.
 
[8]  D.S. Jacobs, W.D. Edwards, R.C. Ye, Metastatic atypical fibroxanthoma of skin, Cancer, 35 (1975), pp. 457-463.
 
[9]  Lee SM, Zhang W, Fernandez MP. Atypical fibroxanthoma arising in a young patient with Li-Fraumeni syndrome. J Cutan Pathol. 2014 Mar;41(3): 303-7.
 
[10]  Brown GE, Madray MM, Greene JF Jr, Fiala KH. Atypical fibroxanthoma in an African American woman. Arch Dermatol. 2010 Sep; 146(9):1045-7. PMID: 20855713.
 
[11]  Berk DR, Lind AC, Tapia B, Kane AA, Bayliss SJ. Atypical fibroxanthoma in a child without xeroderma pigmentosum. Pediatr Dermatol. 2007 Jul-Aug; 24(4): 450-2.
 
[12]  Chappell AG, Chase EP, Chang B, Cunningham E, Mihm F, Calame A, Fudem G, Cunningham B. Atypical Fibroxanthoma in a 13-Year-Old Guatemalan Girl with Xeroderma Pigmentosum. Pediatr Dermatol. 2016 May; 33(3): e228-9.
 
[13]  Sarac E, Yuksel M, Turkmen IC, Ozdemir M. Case for diagnosis. Atypical fibroxanthoma. An Bras Dermatol. 2019; 94(2): 239-241.
 
[14]  Pesapane F, Nazzaro G, Lunardon L, Coggi A, Gianotti R. Two friends with eroded nodules on the ears: atypical fibroxanthoma case report. An Bras Dermatol. 2015; 90(4): 577-579.
 
[15]  Dei Tos AP, Maestro R, Doglioni C, Gasparotto D, Boiocchi M, Laurino L. Ultravioletinduced p53 mutations in atypical fibroxanthoma. Am J Pathol. 1994; 145: 11-17.
 
[16]  Davis JL, Randle HW, Zalla MJ, Roenigk RK, Brodland DG. A comparison of Mohs micrographic surgery and wide excision for the treatment of atypical fibroxanthoma. Dermatol Surg. 1997 Feb; 23(2): 105-10.
 
[17]  J.D. Cizenski, R.S. Farah, Atypical fibroxanthoma arising within erosive pustular dermatosis of the scalp, Cutis, 100 (2017), pp. e14-e16.
 
[18]  Weiss SW, Goldblum JR. Malignant fibrohistiocytic tumors. In: Strauss M, editor. Enzinger and Weiss’s Soft Tissue Tumors. 4th edn. St Louis: Mosby; 2001. pp. 535-69.