Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2022, 10(9), 235-238
DOI: 10.12691/AJMCR-10-9-6
Case Report

An Infant with Mediterranean Spotted Fever in Palestine: A Case Report

Oadi N. Shrateh1, , Raneen R. Sweity1 and Rabee S. Adwan2

1Faculty of Medicine, Al-Quds University, Jerusalem, Palestine

2Infectious Diseases Unit, Makassed Charitable Society Hospital, East Jerusalem, Palestine

Pub. Date: September 20, 2022

Cite this paper

Oadi N. Shrateh, Raneen R. Sweity and Rabee S. Adwan. An Infant with Mediterranean Spotted Fever in Palestine: A Case Report. American Journal of Medical Case Reports. 2022; 10(9):235-238. doi: 10.12691/AJMCR-10-9-6

Abstract

Introduction: Mediterranean spotted fever (MSF) is an emerging and zoonotic disease caused by Rickettsia conorii. The main arthropod vector of this bacterium is Rhipicephalus sanguineus, also called “brown dog tick”. We report a 3-month-old infant affected by MSF as the first reported case of the condition in Palestine. Clinical report: in July 2022, a previously healthy 3-month-old child was admitted to the hospital due to fever, diffuse maculopapular rash and a black spot on his leg. Laboratory assessment revealed thrombocytopenia, hypoalbuminemia, and elevated liver enzymes. Polymerase chain reaction (PCR) testing was positive for Rickettsia Conorii and a diagnosis MSF was ascertained. The patient was completely recovered with doxycycline treatment. Conclusion: Mediterranean spotted fever (MSF) is endemic in Africa, India, Europe and Mediterranean countries; including Palestine. In this case study, we affirm the significance of suspecting MSF in patients presenting with fever and rash even in those who stay in their homes apart from environments with high tick-exposure possibility.

Keywords

mediterranean spotted fever, Palestine, Rickettsia conorii, Rhipicephalus sanguineus, doxycycline

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Rovery C, Raoult D. Mediterranean spotted fever. Infectious disease clinics of North America. 1; 22(3): 515-30, Sep 2008.
 
[2]  Raoult D, Weiller PJ, Chagnon A, Chaudet H, Gallais H, Casanova P. Mediterranean spotted fever: clinical, laboratory and epidemiological features of 199 cases. The American journal of tropical medicine and hygiene. 1; 35(4): 845-50 Jul 1986.
 
[3]  Walker DH. Pathology and pathogenesis of the vasculotropic rickettsioses. Biology of rickettsial diseases.; 1: 115-38,1988.
 
[4]  Brumpt E. Longevity of the Virus of Fièvre boutonneuse in R. sanguineus. Compte rendu des séances de la Société de Biologie.; 110(28): 1199-202, 1932.
 
[5]  Parola P, Paddock CD, Raoult D. Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clinical microbiology reviews. 18(4): 719-56, Oct 2005.
 
[6]  Mansueto S, Barba G, Giammona R, Pecoraro V, Scaffidi L. Mediterranean spotted fever in the past five years (1975-1980): statistical and epidemiological data. Acta Mediterranea di Patologia Infettiva e Tropicale. 1(2): 255-641982.
 
[7]  Raoult D, Dupont HT, Caraco P, Brouqui P, Drancourt M, Charrel C. Mediterranean spotted fever in Marseille: descriptive epidemiology and the influence of climatic factors. European journal of epidemiology. 8(2): 192-7 Mar 1992.
 
[8]  Gilot B, Laforge ML, Pichot J, Raoult D. Relationships between the Rhipicephalus sanguineus complex ecology and Mediterranean spotted fever epidemiology in France. European journal of epidemiology. 6(4): 357-62 Dec 1990.
 
[9]  Herbert WN, Seeds JW, Koontz WL, Cefalo RC. Rocky Mountain spotted fever in pregnancy: differential diagnosis and treatment. Southern Medical Journal. 1; 75(9): 1063-6 Sep 1982.
 
[10]  Crespo P, Seixas D, Marques N, Oliveira J, Da Cunha S, Meliço-Silvestre A. Mediterranean spotted fever: case series of 24 years (1989–2012). SpringerPlus. 4(1): 1-7 Dec 2015.
 
[11]  Anton E, Font B, Munoz T, Sanfeliu I, Segura F. Clinical and laboratory characteristics of 144 patients with Mediterranean spotted fever. European Journal of Clinical Microbiology and Infectious Diseases. 22(2): 126-8 Feb 2003.
 
[12]  Colomba C, Saporito L, Polara VF, Rubino R, Titone L. Mediterranean spotted fever: clinical and laboratory characteristics of 415 Sicilian children. BMC infectious diseases. 6(1): 1-5 Dec 2006.
 
[13]  Spernovasilis N, Markaki I, Papadakis M, Mazonakis N, Ierodiakonou D. Mediterranean spotted fever: Current knowledge and recent advances. Tropical Medicine and Infectious Disease. 24; 6(4):172 Sep 2021.
 
[14]  Papa A, Dalla V, Petala A, Maltezou HC, Maltezos E. Fatal Mediterranean spotted fever in Greece. Clinical microbiology and infection. 1; 16(6): 589-92 Jun 2010.
 
[15]  Raoult D, Roux V. Rickettsioses as paradigms of new or emerging infectious diseases. Clinical microbiology reviews. 10(4): 694-719 Oct 1997.
 
[16]  Walker DH. Rickettsiae and rickettsial infections: the current state of knowledge. Clinical infectious diseases. 15; 45(Supplement_1): S39-44 Jul 2007.
 
[17]  Ericsson CD, Jensenius M, Fournier PE, Raoult D. Rickettsioses and the international traveler. Clinical infectious diseases. 15; 39(10): 1493-9 Nov 2004.
 
[18]  Bella F, Font B, Uriz S, Munoz T, Espejo E, Traveria J, Serrano JA, Segura F. Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever. Antimicrobial agents and chemotherapy.; 34(5): 937-8 May 1990.
 
[19]  Rolain JM, Maurin M, Vestris G, Raoult D. In vitro susceptibilities of 27 rickettsiae to 13 antimicrobials. Antimicrobial agents and chemotherapy. 1; 42(7): 1537-41 Jul 1998.
 
[20]  Biggs, H.M., et al., Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis—United States: A practical guide for health care and public health professionals. Morbidity and Mortality Weekly Report: Recommendations and Reports, 2016. 65(2): p. 1-44.