Hyperphagia- A Rare Clinical Presentation of Acute Lymphoblastic Leukemia Relapse

Yasir Bashir¹, Nusrat Bashir², Sajad Geelani³, Asif Ahmed^4, , Manzoor Parry³, Shabeer Ahmad⁵ and Javid Rasool³

¹Department of Critical care, Sheri-kashmir institute of medical sciences, soura, Srinagar j&k, India

²Department of laboratory hematology, Sheri-kashmir institute of medical sciences, soura, Srinagar, j&k, India

³Department of clinical hematology Sheri-kashmir institute of medical sciences, soura, Srinagar, j&k, India

⁴Department of pediatrics Sheri-kashmir institute of medical sciences, soura, Srinagar, j&k, India

⁵Department of general surgery Sheri-kashmir institute of medical sciences, soura, Srinagar, j&k, India

Cite this paper

Yasir Bashir, Nusrat Bashir, Sajad Geelani, Asif Ahmed, Manzoor Parry, Shabeer Ahmad and Javid Rasool. Hyperphagia- A Rare Clinical Presentation of Acute Lymphoblastic Leukemia Relapse. American Journal of Medical Case Reports. 2014; 2(11):247-249. doi: 10.12691/AJMCR-2-11-6

Abstract

Hyperphagia (also referred to as polyphagia) is a serious eating disorder defined as an extreme unsatisfied drive to consume food and the most common sign that aperson has hyperphagia is obesity. It can be caused commonly by variety of congenital obesity syndromes and rarely by acquired hypothalamic dysfunction.Here we report a clinical manifestation of a child who was a diagnosed case of acute lymphoblastic leukemia and was on maintenance chemotherapy when parents noted her overeating and on evaluation she proved to have central nervous system relapse.

Keywords

hyperphagia, acute lymphoblastic leukemia, relapse

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Pui CH, Jeha S. New therapeutic strategies for the treatment of acute lymphoblastic leukaemia. Nat Rev Drug Discov 6 (2): 149-65, 2007.
[2]	LocatelliF, Schrapp M, Bernard ME, and Rutella S.How I treat relapsed childhood acute lymphoblastic leukemia. . October 4, 2012.
[3]	Gaynon PS, Childhood acute lymphoblastic leukaemia and relapse. Br Haematol; 131 (5): 579-587. 2005.
[4]	Rizzari C, Valsecchi MG, Arico M, et al Outcome of very late relapse in children with acute lymphoblastic leukemia. Haematologica; 89 (4): 427-434. 2004.
[5]	Bailey LC, Lange BJ, Rheingold SR, Bunin NJ,Bone-marrow relapse in paediatric acute lymphoblastic leukaemia. Lancet Oncol; 9 (9):873-883. 2008.
[6]	Ford AM, Fasching K, Panzer, Grumayer ER, Koenig M, Haas OA, Greaves MF Origins of “late” relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. Blood; 98 (3): 558-564. 2001.
[7]	Tallen G, Ratei R, Mann G, et al. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J Clin Oncol 28 (14): 2339-2347. 2010.
[8]	Herold R, von Stackelberg A, Hartmann R, Eisenreich B,Henze G. Acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group (ALL-REZ BFM) experience: early treatment intensity makes the difference. J Clin Oncol; 22 (3): 569-570. author reply 570-561. 2004.
[9]	Memis A, Killi R, Orguc S, et al Bilateral breast involvement in acute lymphoblastic leukemia: color Doppler sonography findings. AJR (Am J Roentgenol) 165: 1011. 1995.