Synchronous Triple Distinct Urological Tumors in a Patient: Urothelial Carcinoma of Bladder, Unilateral Renal Oncocytoma and Papillary Adenoma

Sevinç Şahin^1, , Selda Seçkin¹, Kürşad Zengin², Serhat Tanık² and Mesut Gürdal²

¹Bozok University School of Medicine, Department of Pathology

²Bozok University School of Medicine, Urology Clinic

Cite this paper

Sevinç Şahin, Selda Seçkin, Kürşad Zengin, Serhat Tanık and Mesut Gürdal. Synchronous Triple Distinct Urological Tumors in a Patient: Urothelial Carcinoma of Bladder, Unilateral Renal Oncocytoma and Papillary Adenoma. American Journal of Medical Case Reports. 2014; 2(11):250-252. doi: 10.12691/AJMCR-2-11-7

Abstract

Synchronous multiple primary tumors of the urinary tract are quite rare. The medical literature refers to a small percentage (around 4%) of the incidence of oncocytomas synchronous with other kidney tumors as renal cell carcinoma, pelvic urothelial carcinoma, angiomyolipoma etc. Papillary adenoma is one of those tumors that may rarely coexist with oncocytoma. In this study, we present a case of 69-year-old male patient with synchronous occurrence of concomittant unilateral renal oncocytoma and papillary adenoma, and urothelial carcinoma in bladder. To the best of our knowledge, this is the first case report combining those urinary tumors in the medical literature.

Keywords

Synchronous, urinary tract, urothelial carcinoma, oncocytoma, papillary adenoma

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Lopez-Beltran, A., Amin, M.B., Oliveira, P.S., Montironi, R., Algaba, F., Mcytokeratinenney, J.K. et al. “Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis,” Am J Surg Pathol, 34 (3). 371-6. March. 2010.
[2]	Eble, J.N., Sauter, G., Epstein, J.I., Sesterhenn, I.A. World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press, Lyon, 2004, 41-42.
[3]	Liu, L., Qian, J., Singh, H., Meiers, I., Zhou, X., Bostwicytokeratin, D.G. “Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis,” Arch Pathol Lab Med, 131 (8). 1290-7. August. 2007.
[4]	Petersen, R.O., Sesterhenn, I.A., Davis, C.J. Urologic Pathology, Lippincott Williams & Wilkins, 2009, 42-6.
[5]	Kolníková, G., Marinová, P., Gál, V., Mečiarová, I., Mišanko, V., Rampalová, J., Jáni, P. et al. “Renal oncocytoma with invasive histopathologic features -  case report,” Klin Onkol, 27 (2). 138-42. 2014.
[6]	Sirintrapun, S.J., Geisinger, K.R., Cimic, A., Snow, A., Hagenkord, J., Monzon, F., et al. “Oncocytoma-like renal tumor with transformation toward high-grade oncocytic carcinoma: a unique case with morphologic, immunohistochemical, and genomic characterization,” Medicine (Baltimore), 93 (15). 81. Sep.2014.
[7]	Burger, M., Denzinger, S., Filbeck, T., Hartmann, A., Rössler, W., Hammerschmied, C. “A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature,” Scientific World Journal, 5 (1). 545-9. July. 2005.
[8]	Bezircioğlu, İ., Baloğlu, A., Karcı, L., Çetinkaya, B., Yiğit, S. “Synchronous renal oncocytoma, endometrioid ovarian and endometrial carcinoma: a case report,” J Turkish-German Gynecol Assoc, 10 (1). 43-46. 2009.
[9]	Dogra, P.N., Yadav, S.V., Safaya, R. “Concomitant renal oncocytoma and bladder tumor: a case report,” Indian J Cancer, 31 (2). 141-143. Jun. 1994.
[10]	Gatto, A., Falvo, L., Sebastiani, S., Roncolini, G., Pinna, G. “Triple synchronous tumours of the urinary system with different histologies: a case report,” Chir Ital, 61 (3). 381-385. May-Jun.2009.
[11]	Gonçalves, R., Linhares, E., Albagli, R., Valadão, M., Vilhena, B., Romano, S., et al. “Occurrence of other tumors in patients with GIST,” Surg Oncol, 19 (4). 140-143. Dec.2010.
[12]	Ferreira. S.S., Werutsky, G., Toneto, M.G., Alves, J.M., Pianta, C.D., Breunig, R.C., et al. “Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: case series of a single institution experience,” Int J Surg, 8 (4). 314-317. Apr.2010.