Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2015, 3(4), 111-112
DOI: 10.12691/AJMCR-3-4-7
Case Report

A Case of Acute Myeloid Leukemia with Bilateral Leukemic Optic Nerve Infiltration

Yıldırım Rahşan1, Urlu Selin Merih2, Sincan Gülden1, , Kaban Göktürk2, Karaman Adem3 and Bilen Yusuf1

1Atatürk University, School of Medicine, Departments of Haematology, Erzurum, TURKEY

2Atatürk University, School of Medicine, Departments of Internal Medicine, Erzurum, TURKEY

3Atatürk University, School of Medicine, Departments of Radiology, Erzurum, TURKEY

Pub. Date: March 20, 2015
Full Text PDF

Cite this paper

Yıldırım Rahşan, Urlu Selin Merih, Sincan Gülden, Kaban Göktürk, Karaman Adem and Bilen Yusuf. A Case of Acute Myeloid Leukemia with Bilateral Leukemic Optic Nerve Infiltration. American Journal of Medical Case Reports. 2015; 3(4):111-112. doi: 10.12691/AJMCR-3-4-7

Abstract

Ocular involvement in patients with leukemia may be due to various reasons and it is characterized by various clinical symptoms. Ocular problems in patients who have acute myeloid leukaemia (AML) are commonly observed. Orbital and ocular lesions carry a poor prognosis in patients with acute myeloid leukemia. Direct invasion of the retina and choroid with the neoplastic cells is common, but the involvement of the optic nerve, uveal tract are relatively rare. Ocular symptoms include blurred vision and diplopia due to the involvement of optic nerves. This paper reports a 68 year old patient with AML. 5 azasitidin was initiated for treatment. By the second cycle, he complained of vision loss for right eye. These findings occured for left eye after three days. Optic nerve involvement was found with orbital magnetic resonance imaging with contrast. We report these patient because of rarity.

Keywords

acute myeloid leukemia, diplopia, optic nerve infiltration, vision loss

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Sharma T, Grewal J, Gupta S. Ophthalmic manifestations of acute leukaemias the ophthalmologist’s role. Eye. 18. 663-672. 2004.
 
[2]  Macintyre E, Flandrin G. Biological classification of acute leukemias: federalization or centralization? Leukemia. 9. 2152-2154. 1995.
 
[3]  Leonardy NJ, Rupani M, Dent G, K. K. Gordon. Analysis of 135 autopsy eyes for ocular involvoment in leukemia. Am J Opthalmol. 109. 436-444. 1990.
 
[4]  Woei-A-Jin S; Ypma P; van den Biesen P. Bilateral optic nerve infiltration in a patient with acute myeloid leukaemia. Br J Haematol. 153 (1). 2. 2011.
 
[5]  Schachat AP, Markowitz JA, Guyer DR, Burke P.J, Karp J.E, Graham M.L. Opthalmic manifestations of leukemia. Arch Ophthalmol. 107. 697-700. 1989.
 
[6]  Lisa S, Mtevenina M.G, Nicholas J.V. Bilateral optic nerve infiltration in central nervous system leukemia American Journal of Ophthalmology. 135 (1). 94-96. 2003.
 
[7]  Kincaid MC, Green WR. Ocular and orbital involvoment in leukemia. Surv Ophthalmol 27. 211-232. 1983.
 
[8]  Karesj JW, Goldman EJ, Reck K, Kelman S.E, Lee E.J, Schiffer C.A. A prospective ophthalmic evaluation of patients with acute myeloid leukemia: correlation of ocular and hematologic findings. J Clin Oncol. 7 (10). 1528-1532. 1989.
 
[9]  Rosenthal AR. Ocular manifestation of leukemia: A review. Ophthalmology. 90. 899-905. 1983.
 
[10]  Schwartz CL, Miller NR, Wharam MD, Leventhal B.G. The optic nerve as the site of initial relapse in childhood acute lymphoblastic leukemia. Cancer. 63. 1616-1620. 1989.