Transitional Cell Papilloma of Nasal Cavity with Malignant Transformation

Vijaya KJ¹, Kaur P^1, , Khurana A¹, Chauhan A¹, Singh G² and Parmar P²

¹Department of Radiotherapy, Regional Cancer Centre, Pt. BD Sharma, PGIMS, Rohtak, India

²Departments of Pathology, Pt. BD Sharma, PGIMS, Rohtak, India

Cite this paper

Vijaya KJ, Kaur P, Khurana A, Chauhan A, Singh G and Parmar P. Transitional Cell Papilloma of Nasal Cavity with Malignant Transformation. American Journal of Medical Case Reports. 2015; 3(8):231-234. doi: 10.12691/AJMCR-3-8-3

Abstract

Inverted papilloma of nasal cavity is a rare tumor which is most commonly seen in 5^th to 7^th decade. A case is described here occurring in a 55 year old male who presented with left nasal cavity obstruction and bleeding from the left nose. The patient underwent incisional biopsy from growth nasal cavity which was suggesting transitional cell papilloma with suggestion of malignant transformation following by which the patient underwent left side lateral rhinotomy. Microscopic findings established the diagnosis of transitional cell carcinoma. Patient was later treated by external beam radiation therapy of dose 60 Gy in 30 fractions to the local site. Twenty months after treatment completion patient is on regular follow up and disease free on clinical and radiological examination.

Keywords

transitional cell papilloma, nasal cavity, transitional cell carcinoma, rhinotomy, radiation therapy

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Brown JH, Chew FS. Inverted papilloma. American Journal of Roentgenology. 1992; 159(2): 278.
[2]	Segal K, Atar E, Mor C, Har-El G, Sidi J. Inverting papilloma of the nose and paranasal sinuses. Laryngoscope. 1986; 96(4): 394-398.
[3]	Figuerola E, Liern M, Sánchez Palomero JM, Miró J, Llano JA, Rosell RM, Lluansi J Acta Otorrinolaringol Esp. 1990 Jan-Feb; 41(1): 35-8.
[4]	Reference Inverted Sinonasal Schneiderian Papilloma With Malignant Transformation.
[5]	Wassef SN, Batra PS, Barnett S. Skull base inverted papilloma: a comprehensive review. ISRN Surg. 2012; 2012: 175903.
[6]	Nakano T, Cho H, Sugita M, Shiotani H, Matsumoto Y, Yamada K. A case of a nasal cavity inverted papilloma treated with a local injection of β-interferon. Practica Otologica. 1999; 92(11): 1201-1204.
[7]	Woodcock M, Mollan SP, Harrison D, Taylor D, Lecuona K. Mitomycin C in the treatment of a Schneiderian (inverted) papilloma of the lacrimal sac. Int Ophthalmol. 2010 Jun; 30(3): 303-5.
[8]	Reh DD, Lane AP. The role of endoscopic sinus surgery in the management of sinonasal inverted papilloma. Curr Opin Otolaryngol Head Neck Surg. 2009 Feb; 17(1): 6-10.
[9]	Bajaj MS, Pushker N. Inverted papilloma invading the orbit. Orbit. 2002 Jun; 21(2): 155-9.
[10]	Mendenhall WM, Hinerman RW, Malyapa RS, Werning JW, Amdur RJ, Villaret DB, et al. Inverted papilloma of the nasal cavity and paranasal sinuses. Am J Clin Oncol. 2007 Oct; 30(5): 560-3.
[11]	Levendag PC, Annyas AA, Escajadillo JR, Elema JD. Radiotherapy for inverted papilloma: a case report. Radiother Oncol. 1984 Jun; 2(1):13-7.
[12]	Hug EB, Wang CC, Montgomery WW, Goodman ML. Management of inverted papilloma of the nasal cavity and paranasal sinuses: importance of radiation therapy. Int J Radiat Oncol Biol Phys. 1993; 26: 67-72.
[13]	Jha AK, Goyal A, Sharma S, Upadhyay S, Mishra SC, Sah SP et al. Inverted papilloma of nose with orbital involvement and malignant transformation. Indian Journal of otolaryngology and head and neck surgery. 2003 Apr-Jun; 55 (2).