Extra-Ocular Sebaceous Carcinoma of the Skin: A Report of Five Cases and a Review of the Literature

Mariem MOHAMED^1, , Lobna BOUSSOFARA², Abdlefaddeh SLAMA³, Mohamed DENGUEZLI², Colandane BELAJOUZA², Bedreddine SRIHA⁴, Najet GHARIANI² and Rafiaa NOUIRA²

¹Dermatology Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia

²Dermatology Departments, Farhat Hached University Hospital, Sahloul University Hospital, Sousse, Tunisia

³Oral and Maxillo-Facial Surgery Department, Sahloul University Hospital, Sousse, Tunisia

⁴Pathology Departments, Farhat Hached University Hospital, Sahloul University Hospital, Sousse, Tunisia

Cite this paper

Mariem MOHAMED, Lobna BOUSSOFARA, Abdlefaddeh SLAMA, Mohamed DENGUEZLI, Colandane BELAJOUZA, Bedreddine SRIHA, Najet GHARIANI and Rafiaa NOUIRA. Extra-Ocular Sebaceous Carcinoma of the Skin: A Report of Five Cases and a Review of the Literature. American Journal of Medical Case Reports. 2015; 3(9):291-296. doi: 10.12691/AJMCR-3-9-8

Abstract

Background: Extra ocular sebaceous carcinoma is a rare aggressive adnexal tumour. The diagnosis of this tumour is difficult due to the variety of its clinical and histopathological features. The prognosis is actually considered as aggressive as the ocular counterpart. Methods and results: We propose to discuss the clinical features, histopathological findings and aggressive potential of extra ocular sebaceous carcinoma. Therefore, five extra ocular sebaceous carcinoma cases, diagnosed at the Dermatology and Pathology departments of Farhat Hached Hospital, from January 1998 to December 2007, were reviewed. The diagnosis was based on a histopathological examination. Three of them developed locoregional and/or distant metastases. One patient died from metastatic disease. Surgery was the mainstay of treatment without any cutaneous recurrence after a mean follow-up of two years. Conclusions: Extra ocular sebaceous carcinoma has an unpredictable prognosis. It can be highly aggressive and cause death. Surgery remains the mainstay of treatment.

Keywords

sebaceous adenocarcinoma, extra ocular sebaceous carcinoma, skin cancer, prognosis, surgery

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM. Sebaceous carcinoma. J Am Acad Dermatol 1995; 33: 1-15.
[2]	Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 2009; 115(1): 158-65.
[3]	Bailet JW, Zimmerman MC, Arnstein DP, Wollman JS, Mickel RA. Sebaceous carcinoma of the head and neck. Case report and literature review. Arch Otolaryngol Head Neck Surg 1992; 118: 1245-1249.
[4]	Moreno C, Jacyk WK, Judd MJ, Requena L. Highly aggressive extraocular sebaceous carcinoma. Am J Dermatopathol 2001; 23: 450-455.
[5]	Bassetto F, Baraziol R, Sottosanti MV, Scarpa C, Montesco M. Biological behavior of the sebaceous carcinoma of the head. Dermatol Surg 2004; 30: 472-476.
[6]	Kuwahara RT, Rudolph TM, Skinner RB Jr, Rasberry RD. A large ulcerated tumor on the back. Diagnosis: solitary giant sebaceous carcinoma in a human immunodeficiency virus-positive patient. Arch Dermatol 2001; 137: 1367-1372.
[7]	Alawi F, Siddiqui A. Sebaceous carcinoma of the oral mucosa: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99: 79-84.
[8]	Gomes CC, Lacerda JC, Pimenta FJ, do Carmo MA, Gomez RS. Intraoral sebaceous carcinoma. Eur Arch Otorhinolaryngol 2007; 264: 829-832.
[9]	Liu CJ, Chang KW, Chang RC. Sebaceous carcinoma of buccal mucosa. Report of a case. Int J Oral Maxillofac Surg 1997; 26: 293-294.
[10]	Torres JS, Amorim AC, Hercules FM, Kac BK. Giant extraocular sebaceous carcinoma: case report and a brief review of a literature. Dermatol Online J 2012; 18(11): 7.
[11]	Weedon D. Sebaceous tumours. In: Weedon D. Skin Pathology. 2nd ed. London: Churchill Livingstone; 2002. p. 876-7.
[12]	Buitrago W, Joseph AK. Sebaceous carcinoma: the great masquerader: emgerging concepts in diagnosis and treatment. Dermatol Ther 2008; 21(6): 459-66.
[13]	Ansai S, Mihara I. Sebaceous carcinoma arising on actinic keratosis. Eur J Dermatol 2000; 10: 385-388.
[14]	Kazakov DV, Calonje E, Zelger B, Luzar B, Belousova IE, Mukensnabl P, et al. Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol 2007; 29: 242-248.
[15]	Vartanian RK, McRae B, Hessler RB. Sebaceous carcinoma arising in a mature cystic teratoma of the ovary. Int J Gynecol Pathol 2002; 21: 418-421.
[16]	Cohn ML, Callender DL, El-Naggar AK. Sebaceous carcinoma ex-pleomorphic adenoma: a rare phenotypic occurrence. Ann Diagn Pathol 2004; 8: 224-226.
[17]	Shalin SC, Lyle S, Calonje E, Lazar AJ. Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology 2010; 56(1): 133-47.
[18]	Schwartz RA, Torre DP. The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol 1995; 33: 90-104.
[19]	Duman DG, Ceyhan BB, Celikel T, Ahiskali R, Duman D. Extraorbital sebaceous carcinoma with rapidly developing visceral metastases. Dermatol Surg 2003; 29: 987-989.
[20]	Antuña SA, Méndez JG, Cincunegui JA, López-Fanjul JC. Metastatic lesion of the cervical spine secondary to an extraocular sebaceous carcinoma. Acta Orthop Belg 1996; 62: 229-232.
[21]	Tan O, Ergen D, Arslan R. Sebaceous carcinoma on the scalp. Dermatol Surg 2006; 32: 1290-1293.
[22]	Conill C, Toscas I, Morilla I, Mascaró JM Jr. Radiation therapy as a curative treatment in extraocular sebaceous carcinoma. Br J Dermatol 2003; 149: 441-442.
[23]	Bouraoui S, Khaddar RK, Mokni M, Badri T, Azaiez MY, Dhahri AB. [Extrapalpebral sebaceous carcinoma]. Ann Dermatol Venereol 2006; 133: 165-167.