Unicentric Mixed Variant Castleman Disease Associated with Brachiocephalic Vein Thrombosis: A Rare Presentation

Imene Boukhris^1, , Hana Zoubaidi¹, Ines Kechaou¹, Eya Cherif¹, Nadia Znaidi², Aicha Ben Miled³ and Narjes Khalfallah¹

¹Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

²Department of Diagnostic Pathology, University hospital of Charles Nicolle, Tunis, Tunisia

³Department of Radiology, University hospital of Charles Nicolle, Tunis, Tunisia

Cite this paper

Imene Boukhris, Hana Zoubaidi, Ines Kechaou, Eya Cherif, Nadia Znaidi, Aicha Ben Miled and Narjes Khalfallah. Unicentric Mixed Variant Castleman Disease Associated with Brachiocephalic Vein Thrombosis: A Rare Presentation. American Journal of Medical Case Reports. 2016; 4(10):339-342. doi: 10.12691/AJMCR-4-10-3

Abstract

Castleman disease (CD) is an uncommon lymphoproliferative disorder occurring mostly in patients presenting with mediastinal lymphadenopathy. Predominant phenotypes are categorized as localized hyaline vascular or multicentric plasma cell variants. Localized form of CD is usually asymptomatic and rarely associated with deep venous thrombosis. We report an exceptional case of mediastinal CD, which presented as retrosternal chest pain, in a 42-year old man. Imaging and pathological examination showed an atypical, mixed and localized form of CD. Thoracic CT scan revealed brachiocephalic vein thrombosis. Investigations didn’t reveal other risk factors for deep venous thrombosis. Deep venous thrombosis is an exceptional complication of localized variants of CD. Therefore, it seems worth looking carefully for this last type of benign lymphopathy when an unusual thrombosis is found.

Keywords

castleman disease, venous thrombosis, lymphadenopathy

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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