American Journal of Medical Case Reports. 2016, 4(2), 51-54
DOI: 10.12691/AJMCR-4-2-5
Primary Signet-ring Cell Carcinoma of the Uterine Corpus: A Case Report and Review of the Literature
Shivali P. Marketkar1, Taslima Hossain1, W. Dwayne Lawrence1 and M. Ruhul Quddus1,
1Department of Pathology, Women & Infants Hospital/Alpert Medical School of Brown University, Providence, RI 02905
Pub. Date: February 27, 2016
Cite this paper
Shivali P. Marketkar, Taslima Hossain, W. Dwayne Lawrence and M. Ruhul Quddus. Primary Signet-ring Cell Carcinoma of the Uterine Corpus: A Case Report and Review of the Literature.
American Journal of Medical Case Reports. 2016; 4(2):51-54. doi: 10.12691/AJMCR-4-2-5
Abstract
Pure signet-ring cell carcinomas of the uterine corpus usually raise the suspicion for a metastatic tumor from other primary sites, e.g., breast or the gastrointestinal tract. And if primary in the uterus, it is more commonly of uterine cervical origin with secondary involvement of the corpus. In general, pure mucinous carcinoma of the endometrium is rare and pure signet-ring cell carcinoma, a form of mucinous carcinoma, is even rarer. Only sparse case reports of primary mucinous adenocarcinoma of the uterine corpus with signet-ring cell features have been described in literature. We report here a case of pure mucinous signet-ring cell carcinoma of the uterine corpus in a 63 year-old morbidly obese woman.
Keywords
signet-ring cell, mucinous carcinoma, endometrial carcinoma, uterus, low grade carcinoma, mucicarmine satin
Copyright
This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
References
[1] | Boyd C, Cameron I, McCluggage WG. Endometrial adenocarcinoma with signet ring cells: report of two cases of an extremely rare phenomenon. Int J Gynecol Pathol 2010;29:579-82. |
|
[2] | Chebib I, Chu P, Duggan MA, DiFrancesco LM. Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. Int J Gynecol Pathol 2010; 29:269-72. |
|
[3] | Teresa Pusiol. HPV11 Positive Endometrioid Carcinoma of the Endometrium with Signet-Ring Cells: Diagnostic Criteria and Review of the Literature. Case Reports in Pathology 2014, Article ID 380571, 6. |
|
[4] | Mooney EE1, Robboy SJ, Hammond CB, Berchuck A, Bentley RC Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis. Int J Gynecol Pathol 1997; 16: 169-72. |
|
[5] | Kurman RJ, Carcangui ML, Harrington, CS, Young RH eds. Tumors of the uterine corpus. WHO Classification of Tumors of Female Reproductive Organs. 4th edn. IARC, Lyon 2014; p 18-139. |
|
[6] | Alomari A, Abi-Raad R, Buza N, Hui P. Frequent KRAS mutation in complex mucinous epithelial lesions of the endometrium. Mod Patho 2014;27:675-80. |
|
[7] | Kumar A, Schneider V. Metastases to the uterus from extrapelvic primary tumors. Int 1983; 2:134-40. |
|
[8] | Iezzoni JC, Mills SE. Non-neoplastic endometrial signet-ring cells. Vacuolated decidual cells and stromal histiocytes mimicking adenocarcinoma. Am J Clin Pathol. 2001; 115:249-55. |
|
[9] | Akhter S, Lawrence WD, Quddus MR. Polypoid nodular histiocytic hyperplasia associated with endometrioid adenocarcinoma of the endometrium: report of a case. Diag Pathol 2014; 9:93-97. |
|
[10] | Carlier MT, Dardick I, Lagace AF, Sreeram V. Adenomatoid tumor of uterus: presentation in endometrial curettings. Int J Gynecol Pathol 1986; 5:69-74. |
|