Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2016, 4(5), 150-152
DOI: 10.12691/AJMCR-4-5-1
Case Report

Mullerian Adenosarcoma Occurring in a Young Female and Originally Diagnosed as an Endometrial Stromal Nodule

Modupeola O. Samalia1, Tara Chang2, M. Ruhul Quddus3, , C. James Sung3, Katrine Hansen3 and W. Dwayne Lawrence3

1Department of Pathology & Morbid Anatomy, Ahmadu Bello University & Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

2Middle Tennessee Medical Center, Murfreesboro, TN

3Department of Pathology, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA

Pub. Date: May 04, 2016
Full Text PDF

Cite this paper

Modupeola O. Samalia, Tara Chang, M. Ruhul Quddus, C. James Sung, Katrine Hansen and W. Dwayne Lawrence. Mullerian Adenosarcoma Occurring in a Young Female and Originally Diagnosed as an Endometrial Stromal Nodule. American Journal of Medical Case Reports. 2016; 4(5):150-152. doi: 10.12691/AJMCR-4-5-1

Abstract

Mullerian Adenosarcoma (MA) is most commonly encountered in postmenopausal females in the sixth decade of life. We present the case of a 21-year old female with a high BMI and a clinical presentation suggestive of polycystic ovarian disease; she presented with abnormal vaginal bleeding. A laparoscopy/hysteroscopy by her primary physician demonstrated an intracavitary and submucosal appearing mass which was clinically considered to be a polypoid submucosal leiomyoma. The patient underwent endometrial curettage. The specimen was comprised of multiple fragments of soft tan-red haemorrhagic tissues aggregating to 6.5 x 4.0 x 0.6 cm. An original diagnosis of endometrial stromal nodule was made on this material; however, on consultative review the diagnosis was changed to a mullerian adenosarcoma. No stromal overgrowth or heterologous differentiation was identified. Immunohistochemical studies demonstrated stromal cells were positive for oestrogen receptor (ER) and CD10. We emphasize the young age of this patient with a mullerian adenosarcoma as well as the pitfall of making a specific diagnosis of endometrial stromal neoplasms based on an endometrial curettage.

Keywords

Mullerian Adenosarcoma, endometrial stromal nodule, submucosal mass, endometrial curettage, young patient, diagnostic pitfall

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  McCluggage WG. Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol 2010;17:122-29.
 
[2]  Nucci MR, Quade BJ. Adenosarcoma, Mixed Epithelial and Mesenchymal Tumors, Uterine Mesenchymal Tumors In: Crum CP, Nucci MR, Lee KR (eds). Diagnostic Gynecology and Obstetrics Pathology 2nd ed Elsevier Saunders; 2011:625-6.
 
[3]  Yang C, Oh HK, Kim D. Mullerian adenosarcoma arising from rectal endometriosis. Ann Coloproctol 2014; 30:232-6.
 
[4]  Clement PB. Mullerian adenosarcoma of the uterus with sarcomatous overgrowth: a clinicopathologic analysis of 10 cases. Am J Surg Pathol 1989; 13:28-38.
 
[5]  Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathological analysis of 100 cases with a review of the literature. Hum Pathol 1990; 21:363-81.
 
[6]  Hallak M, Peipert JF, Heller PB, Sedlacek TV, Schauer GM. Mullerian adenosarcoma of the uterus with sarcomatous overgrowth. J Surg Oncol 1992;51:68-70.
 
[7]  Tjalma WA, Michener CM. Mullerian adenosarcoma of the uterus associated with long term oral contraceptive use. Eur J Obstet Gynecol Reprod Biol 2005;119:253-54.
 
[8]  Clement PB, Oliva E, Young RH. Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen associated endometrial lesions. Int J Gynecol Pathol 1996;15: 222-29.
 
[9]  Robert J Kurman, Maria Luisa Carcangiu, C. Simon Herrington, Robert H Young. Endometrial stromal tumour, Mesenchymal tumours- Tumours of the Uterine corpus In: Robert J Kurman, Maria Luisa Carcangiu, C. Simon Herrington, Robert H Young (eds). World Health Organization Classification of Tumours of the Female Reproductive Organs 4th ed. IARC:Lyon 2014; 141-42.
 
[10]  Soslow RA, Oliva E. Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases. Am J Surg Pathol 2008; 32: 1013-21.