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American Journal of Medical Case Reports. 2016, 4(6), 221-223
DOI: 10.12691/AJMCR-4-6-10
Case Report

Rapidly Metastasizing Sarcomatoid Renal Cell Carcinoma in a 76-year Old Male

Nathaniel Moulton1, Joe Devasahayam1, , Rohini Kannuswamy1, Arul Chandran1 and Hunter Hofmann1

1Univerity of Missouri, United States

Pub. Date: July 09, 2016
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Cite this paper

Nathaniel Moulton, Joe Devasahayam, Rohini Kannuswamy, Arul Chandran and Hunter Hofmann. Rapidly Metastasizing Sarcomatoid Renal Cell Carcinoma in a 76-year Old Male. American Journal of Medical Case Reports. 2016; 4(6):221-223. doi: 10.12691/AJMCR-4-6-10

Abstract

Renal Cell Carcinoma (RCC), the most lethal urological cancer has many variants. A relatively uncommon variant, sarcomatoid RCC (sRCC) is one of the most aggressive morphotypes of RCC. The complexity of this tumor is mainly due to the difficulty in its diagnosis as it can present with relatively subtle symptoms and quickly progress to very advanced stage with unusually rapid metastasis and could be fatal. We present a male patient with this rare tumor who initially presented with vague multi-system complaints. The patient rapidly deteriorated and expired following aggressive therapy and was subsequently found to have metastatic sRCC upon autopsy. We review the characteristic features of sRCC and analyze the clinical presentations, histology, prognosis as well as the atypical presentations of sRCC. This case therefore, highlights the difficulty of diagnosis prior to nephrectomy and reinforces the need for a high degree of suspicion for renal malignancies especially in the older patient.

Keywords

renal cell caner, pyelonephritis, metastasis

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  American Cancer Society. Kidney Cancer. http://www.cancer.org/cancer/kidneycancer/detailedguide/kidney-cancer-adult-what-is-kidney-cancer.
 
[2]  Rini, B.I. Renal Cell Carcinoma. Lancet 2009.
 
[3]  de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, et al.: Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. Am J SurgPathol. 2001; 25: 275-84.
 
[4]  Shuch B, Bratslavsky G, Linehan WM, Srinivasan R. Sarcomatoid Renal Cell Carcinoma: A comprehensive review of the biology and current treatment strategies. The Oncologist. 2012; 17:46-54.
 
[5]  Chao D, Zisman A, Freedland SJ, Pantuck AJ, Said JW, Belldegrun AS. Sarcomatoid renal cell carcinoma: basic biology, clinical behavior, and response to therapy. Urologic Oncology. 2001; 6: 231-238
 
[6]  Nagy V, Schneider H, Valansky L, Sokol L. Sarcomatous Dedifferentiated Renal Cell Carcinoma mimicking a severe purulent kidney infection. Urologia Internationalis. 2006; 76: 77-81.
 
[7]  Sountoulides P, Giovis G, Metaxa L, Panagopoulos V, Kikidakis D, Filintatzi C, Paschalidis K. Sarcomatoid RCC, a Highly Aggressive Subtype of Renal Cell Carcinoma. Global Journal of Pathology and Microbiology. 2013.
 
[8]  Mian BM, Bhadkamkar N, Slaton JW, Pisters PWT, Daliani D, Swanson DA, Pisters LL. Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma. The Journal of Urology. 2002 Jan; 167: 65-70.