Halted Progression of Soft Palate Cancer in a Patient Treated with the Paleolithic Ketogenic Diet Alone: A 20-months Follow-up

Csaba Tóth¹ and Zsófia Clemens^{1, 2,}

¹Paleomedicina Hungary Ltd, Evolutionary Medicine Working Group, Budapest, Hungary, H-1026 Hidász u. 3/A, Budapest, Hungary

²University of Pécs, Department of Neurology, Pécs, Hungary, H-7623 Rét u. 2, Pécs, Hungary

Cite this paper

Csaba Tóth and Zsófia Clemens. Halted Progression of Soft Palate Cancer in a Patient Treated with the Paleolithic Ketogenic Diet Alone: A 20-months Follow-up. American Journal of Medical Case Reports. 2016; 4(8):288-292. doi: 10.12691/AJMCR-4-8-8

Abstract

Introduction: Myoepithelial tumor of the soft palate is associated with rapid progression and poor outcome. The standard care includes surgery with optional radiotherapy and/or chemotherapy. Case report: Here we present a case with myoepithelial tumor of the soft palate where the patient denied conventional treatment options. Instead, the patient started the paleolithic ketogenic diet which resulted in a halted progression of the tumor as evidenced by imaging follow-up. Currently, the patient is on the diet for 20 months, without symptoms and side effects. Conclusion: We conclude that the paleolithic ketogenic diet was effective and safe in this patient.

Keywords

soft palate tumor, myoepithelial tumor, paleolithic diet, ketogenic diet

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Warburg O. “On the Origin of Cancer Cells”. Science 123: 309-14, 1956.
[2]	Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Metabolic management of brain cancer. Biochim Biophys Acta. 1807: 577-94, 2011.
[3]	Seyfried TN, Flores RE, Poff AM, D'Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 35: 515-27, 2014.
[4]	Klement RJ, Kämmerer U. Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutrition & Metabolism. 8: 75, 2011.
[5]	Nebeling LC, Miraldi F, Shurin SB et al. Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. J Am Coll Nutr 14: 202-8, 1995.
[6]	Zuccoli G, Marcello N, Pisanello A et al. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab (Lond) 2010, 22,7:33.
[7]	Schmidt M, Pfetzer N, Schwab M, Strauss I, Kämmerer U. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutr Metab (Lond). 8: 54, 2011.
[8]	Rieger J, Bähr O, Maurer GD et al. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol 44: 1843-52, 2014.
[9]	Seyfried, T. N. Case Studies and Personal Experiences in Using the Ketogenic Diet for Cancer Management, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. 2012.
[10]	Fine EJ, Segal-Isaacson CJ, Feinman RD, Herszkopf S, Romano MC, Tomuta N, Bontempo AF, Negassa A, Sparano JA. Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition. 28: 1028-35, 2012.
[11]	Champ CE, Palmer JD, Volek JS, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Shi W. Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. J Neurooncol. 117: 125-31, 2014.
[12]	Chu-Shore CJ, Thiele EA. Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet. Brain Dev. 32: 318-22, 2010.
[13]	Klement RJ, Sweeney RA. Impact of a ketogenic diet intervention during radiotherapy on body composition: I. Initial clinical experience with six prospectively studied patients. BMC Research Notes. 9: 143, 2016.
[14]	Fine EJ, Segal-Isaacson CJ, Feinman R, Sparano J. Carbohydrate restriction in patients with advanced cancer: a protocol to assess safety and feasibility with an accompanying hypothesis. Commun Oncol 5: 22-6, 2008.
[15]	McClellan WS, Du Bois EF. Clinical calorimetry XLV. Prolonged meat diets with a study of kidney function and ketosis. J Biol Chem 87:651-668, 1930.
[16]	Voegtlin WL. The stone age diet: based on in-depth studies of human ecology and the diet of man. New York: Vantage Press; 1975.
[17]	Cordain L. The paleo diet: lose weight and get healthy by eating the food you were designed to eat. New York: Wiley; 2002.
[18]	Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H. Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. Am J Clin Nutr 102: 922-32, 2015.
[19]	Tóth C., Clemens Z. Type 1 diabetes mellitus successfully managed with the paleolithic ketogenic diet. Int J Case Rep Images 5: 699-703, 2014.
[20]	Tóth C, Clemens Z. A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom. Int J Case Rep Images 6: 752-757. 2015.
[21]	Tóth C., Clemens Z. Successful treatment of a patient with obesity, type 2 diabetes and hypertension with the paleolithic ketogenic diet. Int J Case Rep Images 6: 161-167, 2015.
[22]	Clemens Z., Kelemen A., Fogarasi A., Tóth C. Childhood absence epilepsy successfully treated with the paleolithic ketogenic diet. Neurol Ther 2: 71-6, 2013.
[23]	Clemens, Z., Kelemen, A., Tóth, C. NREM-sleep Associated Epileptiform Discharges Disappeared Following a Shift toward the Paleolithic Ketogenic Diet in a Child with Extensive Cortical Malformation. Am J Med Case Rep 3: 212-215, 2015.
[24]	Tóth C., Clemens Z. Gilbert’s syndrome successfully treated with the paleolithic ketogenic diet. Am J Med Case Rep 3: 117-120, 2015.
[25]	Tóth C, Dabóczi A, Howard M, Miller NJ, Clemens Z. Crohn’s disease successfully treated with the paleolithic ketogenic diet. Int J Case Rep Images 7: 570-578, 2016.
[26]	Seyfried TN, Shelton LM, Mukherjee P. Does the existing standard of care increase glioblastoma energy metabolism? Lancet Oncol. 11: 811-3, 2010.
[27]	Xu T, Liao Z, Tang J, Guod L, Qiub H, Gao Y, Hu W. Myoepithelial carcinoma of the head and neck: A report of 23 cases and literature review. Cancer Treatment Communications. 2: 24-29, 2014.
[28]	Ren J, Liu Z, Liu X, Li Y, Zhang X, Li Z, Yang Y, Yang Y, Chen Y, Jiang S. Primary myoepithelial carcinoma of palate. World J. Surg. Oncol. 9: 104, 2011.
[29]	Boers I, Muskiet FA, Berkelaar E, Schut E, Penders R, Hoenderdos K, Wichers HJ, Jong MC. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study. Lipids Health Dis. 13: 160, 2014.
[30]	Lin JE, Snook AE, Li P et al. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS ONE 7: 2, e31686, 2012.
[31]	Kossoff EH International consensus statement on clinical implementation of the ketogenic diet: agreement, flexibility, and controversy. Epilepsia 49 Suppl 8: 11-3. 2008.