Synchronous Bilateral Breast Cancer (SBBC): Report of a Case with Review of Literature

Mazaher Ramezani¹, Akram Amiri², Farhad Kavousi¹ and Masoud Sadeghi^3,

¹Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

²Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

³Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Cite this paper

Mazaher Ramezani, Akram Amiri, Farhad Kavousi and Masoud Sadeghi. Synchronous Bilateral Breast Cancer (SBBC): Report of a Case with Review of Literature. American Journal of Medical Case Reports. 2017; 5(12):301-303. doi: 10.12691/AJMCR-5-12-5

Abstract

The incidence of synchronous bilateral invasive breast cancer (SBBC) is reported to range from 0.8%-3.0%. Lower disease-free survival and high rates of distant metastasis is a recognized feature of bilateral synchronous tumors, which therefore have a worse overall survival compared to unilateral tumors. Early detection of the contralateral tumor is of utmost importance emphasizing the significance of breast self-examination. Here we report a case of SBBC with invasive ductal carcinoma on both sides in a 50-year-old lady. The pathology report on both sides was infiltrating ductal carcinoma and ductal carcinoma in situ, nuclear grade of ІІ/ІІІ and histologic grade of II/III. Perineural invasion was present on both sides but vascular invasion only on the right side. In conclusion, SBBC is rare, but is important because it may have worse prognosis, different hormone receptor status and treatment modality. Early detection with breast self-examination is highly emphasized.

Keywords

synchronous, bilateral, breast cancer, case report

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Manea E, Munteanu A. Evolution of synchronous bilateral breast carcinoma in a young patient. Rev Med Chir Soc Med Nat Iasi. 2016; 120(1): 192-6.
[2]	Jobsen JJ, van der Palen J, Ong F, Riemersma S, Struikmans H. Bilateral breast cancer, synchronous and metachronous; differences and outcome. Breast Cancer Res Treat. 2015; 153(2): 277-83.
[3]	Baykara M, Ozturk SC, Buyukberber S, Helvaci K, Ozdemir N, Alkis N, et al. Clinicopathological Features in Bilateral Breast Cancer. Asian Pacific J Cancer Prev. 2012; 6(9): 4571-5.
[4]	Karsten M, Stempel M, Radosa J, Patil S, King TA. Oncotype DX in Bilateral Synchronous Primary Invasive Breast Cancer. Ann Surg Oncol. 2016; 23(2): 471-6.
[5]	Kappikeri VKS, Kriplani AM. Bilateral synchronous carcinoma breast- a rare case presentation. Springerplus. 2015;4:193.
[6]	Dalal AK, Gupta A, Singal R, Dalal U, Attri AK, Jain P, et al. Bilateral breast carcinoma– a rare case report. J Med Life. 2011; 4(1): 94-6.
[7]	Saad RS, Denning KL, Finkelstein SD, Liu Y, Pereira TC, Lin X, et al. Diagnostic and Prognostic Utility of Molecular Markers in Synchronous Bilateral Breast Carcinoma. Mod Pathol. 2008; 21(10): 1200-7.
[8]	Schmid SM, Pfefferkorn C, Myrick ME, Viehl CT, Obermann E, Schötzau A, et al. Prognosis of early-stage synchronous bilateral invasive breast cancer. Eur J Surg Oncol. 2011; 37(7): 623-8.
[9]	Kadioğlu H , Özbaş S, Akcan A, Soyder A, Soylu L, Koçak S, et al. Comparison of the histopathology and prognosis of bilateral versus unilateral multifocal multicentric breast cancers. World J Surg Oncol. 2014; 12: 266.
[10]	Esclovon JW, Ponder M, Aydin N, Misra S. Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology. BMJ Case Rep. 2016; 2016.
[11]	Ursaru M, Jari I, Gheorghe L, Naum AG, Scripcariu V, Negru D. Bilateral breast cancer: diagnosis and prognosis. Rev Med Chir Soc Med Nat lasi. 2016; 120(2): 316-20.
[12]	Peiró G, Adrover E, Guijarro J, Ballester I, Jimenez MJ, Planelles M, et al. Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis. Breast J. 2010; 16(1): 77-81.
[13]	Ŝoštarić Zadro A, Fudurić J, Frketić I, Miletić M, Zadro Z, Martinac M, et al. Bilateral synchronous breast cancer. Coll Antropol. 2014; 38(3): 1043-5.