American Journal of Medical Case Reports. 2017, 5(5), 126-128
DOI: 10.12691/AJMCR-5-5-6
A Case of African Visceral Leishmaniasis (VL) Treated with a Combination of Liposomal Amphotericin-B and oral Miltefosine
Alok Agarwal1, , Makardhwaj Sarvadaman Shrivastava1 and Amit Kumar Vishwakarma2
1Internal Medicine, Indraprastha Apollo Hospitals, New Delhi, India
2Biocon Ltd., Bangalore, India
Pub. Date: June 16, 2017
Cite this paper
Alok Agarwal, Makardhwaj Sarvadaman Shrivastava and Amit Kumar Vishwakarma. A Case of African Visceral Leishmaniasis (VL) Treated with a Combination of Liposomal Amphotericin-B and oral Miltefosine.
American Journal of Medical Case Reports. 2017; 5(5):126-128. doi: 10.12691/AJMCR-5-5-6
Abstract
A 36-year-old Nigerian man was assessed for chronic recurrent fever, generalized weakness, body aches, epistaxis and bleeding gums of 3-month duration. Despite receiving treatment for suspected malaria twice and undergoing multiple courses of antibiotics for suspected infections, his symptoms persisted. Examination revealed hepatosplenomegaly, lymphadenopathy, and severe pallor. Investigations revealed severe anemia, pancytopenia, raised globulin levels. Bone marrow biopsy revealed Leishmania Donovani (LD) bodies. He received treatment with a short duration of high-dose liposomal Amphotericin B followed by outpatient oral Miltefosine to which he responded successfully.
Keywords
infections, visceral leishmaniasis, VL, Amphotericin-B, Miltefosine, black fever, Kala-azar
Copyright
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