Gastric Sarcoidosis: An Atypical Presentation of a Rare Disease

Yanardag H¹, Tetikkurt C^2, , Bilir M^1, , Kepil N³ and Verdi Y¹

¹Department of Internal Medicine Medicine, Cerrahpasa Medical Faculty, Istanbul University

²Department of Pulmonary Medicine, Cerrahpasa Medical Faculty, Istanbul University

³Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University

Cite this paper

Yanardag H, Tetikkurt C, Bilir M, Kepil N and Verdi Y. Gastric Sarcoidosis: An Atypical Presentation of a Rare Disease. American Journal of Medical Case Reports. 2017; 5(6):135-140. doi: 10.12691/AJMCR-5-6-1

Abstract

Sarcoidosis is a multisystemic granulomatous disease characterised by the histologic evidence of granulomas in various organs. Clinically discernible gastric sarcoidosis is extremely rare, reported in less than 1% of the patients. We present a case of gastric sarcoidosis with atypicial manifestations and without current pulmonary disease. The patient was admitted for gastric fullness, anorexia, and weight loss. She had a history of migraine and nodular goiter. Family history revealed bladder carcinoma in the mother and gastric carcinoma in the uncle. Initial laboratory findings and chest x-ray were normal. Biopsies from the gastric mucosa revealed noncaseating granulomas with focal multinucleate giant cells. Six months after the patient was admitted for dry cough and fatigue. Chest x-ray and CT revealed diffuse nodules in the upper and middle lung zones. Transbronchial biopsy demonstrated noncaseiting granulomas compatible with sarcoidosis. The patient was started on mehtylprednisolone and had a significant improvement in her symptoms. This case is an unique paradigm for the exceptional presentation of sarcoidosis. Isolated extrapulmonary organ involvement without simultaneous lung disease may be the initial manifestation of sarcoidosis. Meticulous follow-up for sarcoidosis is required for patients presenting with atypical symptoms and noncaseiting granulomas in any extrapulmonary organ.

Keywords

sarcoidosis, stomach, gastric

Copyright

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