Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature

Apoorva Jayarangaiah¹, Pramod Theetha Kariyanna², Tanuj Chokshi², Maya Srinivasan², Seline Asun², Michael Ashamalla², Irini Youssef² and Samy I McFarlane^2,

¹Department of Internal Medicine, NYC Health and Hospitals/Jacobi Medical Center, Bronx, N.Y., U.S.A- 10461

²Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203

Cite this paper

Apoorva Jayarangaiah, Pramod Theetha Kariyanna, Tanuj Chokshi, Maya Srinivasan, Seline Asun, Michael Ashamalla, Irini Youssef and Samy I McFarlane. Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature. American Journal of Medical Case Reports. 2019; 7(1):9-12. doi: 10.12691/AJMCR-7-1-3

Abstract

Leukocytosis, specifically granulocytosis in malignancy is a common finding with various etiologies. Graulocytosis associated with esophageal cancer has not commonly been reported in case reports in the United States. Furthermore, granulocyte colony stimulating factor (G-CSF) producing tumors have been associated with a variety of cancers. However, G-CSF producing esophageal tumors are rare. The diagnosis is established through serum G-CSF levels and immunohistochemistry staining of tumor cells. Here, we report a case of a 72-year-old woman with persistent granulocytosis leading to the diagnosis of esophageal squamous cell carcinoma (ESCC). Although, our case did not report serum G-CSF levels, we strongly suspect it to be the underlying etiology in our case. Additionally, through our missed opportunity, we hope to emphasize and increase awareness of G-CSF producing ESCC.

Keywords

esophageal squamous cell carcinoma, leukocytosis, granulocyte colony stimulating factor (G-CSF)

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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