Late Presentation of Carfilzomib Associated Thrombotic Microangiopathy

Michael Haddadin¹, Mohammad Al-Sadawi¹, Sally Madanat², Eric Tam³, Evelyn Taiwo³, Carol Luhrs³ and Samy I Mcfarlane^1,

¹Department of internal Medicine, State University of New York-Downstate, Brooklyn, New York, USA

²Saint James School of Medicine St. Vincent, Cane Hall Road, Arnos Vale, St Vincent & the Grenadines

³Department of Hematology & Oncology, State University of New York-Downstate, Brooklyn, New York, USA

Cite this paper

Michael Haddadin, Mohammad Al-Sadawi, Sally Madanat, Eric Tam, Evelyn Taiwo, Carol Luhrs and Samy I Mcfarlane. Late Presentation of Carfilzomib Associated Thrombotic Microangiopathy. American Journal of Medical Case Reports. 2019; 7(10):240-243. doi: 10.12691/AJMCR-7-10-5

Abstract

Multiple Myeloma (MM) is a plasma cell disorder characterized by abnormal proliferation of plasma cells resulting in overproduction of paraprotein. Proteasome inhibitors (PI) have been a corner stone for the treatment of MM. Thrombotic Microangiopathy (TMA) is a recent hematological adverse event that has newly been recognized in multiple PI. TMA leads to end-organ damage and infarction by microthromobi. TMA pathophysiology is not well understood and has multiple etiologies. We present a case of PI-induced TMA, along with literature review of cases diagnosed from 2008-2018. Unique to our case is the onset of presentation, more than 24 months after initiating carfilzomib. Our case highlights the need for vigilant monitoring and the importance of clinical suspicion in patients at risk for TMA.

Keywords

carfilzomib, thrombotic microangiopathy, proteosome inhibitos

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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