Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis

Simin Laiq¹, Jaragh M², Ginsberg H^3, and David G Munoz²

¹Histopathology Department, Directorate General of Khoula Hospital, Muscat, Oman

²Division of Pathology, St. Michael’s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

³Division of Neurosurgery, St. Michael’s Hospital, Department of Surgery, Toronto, Ontario, Canada

Cite this paper

Simin Laiq, Jaragh M, Ginsberg H and David G Munoz. Adult Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation: Case Report with Molecular Analysis. American Journal of Medical Case Reports. 2021; 9(1):71-74. doi: 10.12691/AJMCR-9-1-18

Abstract

Medulloblastoma with myogenic differentiation (MMD), previously termed medullomyoblastoma, is a distinctive subtype of medulloblastoma. It is an uncommon neoplasm in children and very rare in adults, with oldest reported case being 49-years of age. We present a case of large cell/anaplastic medulloblastoma with myogenic differentiation arising in the right cerebellar hemisphere of a 54-year-old man treated by surgical resection and radiotherapy. Despite C-MYC amplification in the tumor, he survived tumor-free for nearly 2 years (726 days), which greatly exceeded the expected total survival. His death was attributed to complications of treatment rather than recurrence.

Keywords

Large cell/anaplastic medulloblastoma with myogenic differentiation, medullomyoblastoma, cerebellum, adult, C-MYC amplification

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Louis DN et al. (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114(2): 97-109.
[2]	Schiffer D, Giordana MT, Pezzotta S, Pezzulo T, Vigliani MC. (1992). Medullomyoblastoma: report of two cases. Child’s Nerv Syst 8: 268-272.
[3]	Ke, C.-S & Deng, Z.-D & Lei, T. & Zeng, L.-C & Wu, S.-M & Wan, J.. (2008). Medullomyoblastoma: Report of an adult case and review of literatures. Chinese Journal of Contemporary Neurology and Neurosurgery. 8. 567-571.
[4]	Marinesco G, Goldstein M. (1933). Sur une forme anatomique, non encore decrite, de medulloblastome: Medullomyoblastome. Ann. Anat. Pathol 10: 513-525.
[5]	Smith T, Davidson R. (1984). Medullomyoblastoma: A histologic, immunohistochemical, and ultrastructural study. Cancer 54: 323-332
[6]	Smith TW, Davidson RI. Medullomyoblastoma. A histologic, immunohistochemical, and ultrastructural study. Cancer 1984; 54: 323-32.
[7]	Helton KJ et al (2004). Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature. Cancer 101(6): 1445-1454.
[8]	Bartlett F, Kortmanny R, Saran F. (2013) Medulloblastoma. Clinical oncology 25: 36-45.
[9]	Yoshino S, Etoh Y, Konishi Y, Iwaki T, Okada H, Nishida T, Imai T, Isobe K, Itoh S, Tamiya T (2011) A case of medullomyoblastoma. Pediatrics International. 53(3): 399-402.
[10]	Rattenberry W, McDonough C H, Burger P C, Cohen K J (2011) Medulloblastoma with myogenic differentiation: long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation. J Neurooncol 105: 659-662.