Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2021, 9(1), 83-87
DOI: 10.12691/AJMCR-9-1-21
Case Report

HIV-associated Hodgkin Lymphoma with a Granulomatous Bone Marrow Biopsy: A Case Report

Gil Hevroni1, Zachary Mostel1, Samara Skwiersky1, Adam Osman2, Moro O. Salifu1 and Isabel M. McFarlane1,

1Department of Internal Medicine, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA

2Department of Pathology, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, USA

Pub. Date: November 27, 2020
Full Text PDF

Cite this paper

Gil Hevroni, Zachary Mostel, Samara Skwiersky, Adam Osman, Moro O. Salifu and Isabel M. McFarlane. HIV-associated Hodgkin Lymphoma with a Granulomatous Bone Marrow Biopsy: A Case Report. American Journal of Medical Case Reports. 2021; 9(1):83-87. doi: 10.12691/AJMCR-9-1-21

Abstract

The incidence of HIV-associated Hodgkin lymphoma has risen during the era of combined antiretroviral therapy (ART) despite the proven, protective effects of ART as treatment for HIV. The clinical presentation of Hodgkin Lymphoma may also resemble disseminated mycobacterial infection - in symptoms, laboratory findings, and even bone marrow biopsy. This is a case report of a patient with HIV who was suspected to have disseminated mycobacterial infection after a first bone marrow biopsy showed granulomatous inflammation and was later found to have HIV-associated Hodgkin lymphoma on a repeat biopsy.

Keywords

HIV, hodgkin lymphoma, granuloma

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Brackers de Hugo L, Ffrench M, Broussolle C, Sève P. Granulomatous lesions in bone marrow: clinicopathologic findings and significance in a study of 48 cases. Eur J Intern Med. 2013 Jul; 24(5): 468-73.
 
[2]  Du J, Zhang Y, Liu D, Zhu G, Zhang Q. Hodgkin's lymphoma with marked granulomatous reaction: a diagnostic pitfall. Int J Clin Exp Pathol. 2019 Jul 1; 12(7): 2772-2774.
 
[3]  Powles T, Robinson D, Stebbing J, et al. Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection. Journal of Clinical Oncology. 2009; 27(6): 884-890.
 
[4]  Eid A., Carion W., Nystrom J.S.: Differential diagnoses of bone marrow granuloma. West J Med. 1996; 164: pp. 510-515.
 
[5]  Berenguer J, Miralles P, Ribera JM, Rubio R, Valencia E, Mahillo B, Pintado V, Palacios R, Montes ML, Téllez MJ, La Cruz J, Torre-Cisneros J, Rodríguez-Arrondo F, Sepúlveda MA, Gutiérrez F, Peralta G, Boix V. Characteristics and outcome of AIDS-related Hodgkin lymphoma before and after the introduction of highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2008 Apr 1; 47(4): 422-8.
 
[6]  Jacobson CA, Abramson JS. HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART. Adv Hematol. 2012; 2012: 507257.
 
[7]  Dargent JL, Schandené L, Kornreich A, Jagodzinski R, Capel P, Velu T, Neve P. TH1-type immune response in lymphocyte-predominance Hodgkin's disease. Br J Haematol. 1995 Nov; 91(3): 775-6.
 
[8]  Khan A, Hill JM, MacLellan A, Loeb E, Hill NO, Thaxton S. Improvement in delayed hypersensitivity in Hodgkin's disease with transfer factor: lymphapheresis and cellular immune reactions or normal donors. Cancer. 1975 Jul; 36(1): 86-9.
 
[9]  Pak HY, Friedman NB. Pseudosarcoid granulomas in Hodgkin's disease. Hum Pathol. 1981 Sep; 12(9): 832-7.
 
[10]  Hou WH, Wei P, Xie JL, Zheng YY, Zhou XG. Classical Hodgkin lymphoma with necrotic granuloma-like morphological features. Int J Clin Exp Med. 2018; 11: 9593-9602.
 
[11]  Aggarwal, P., Sharma, M., Nimbran, V., & Kaur, K. (2018). Hodgkin lymphoma with granulomas. Demystifying the dilemma. Annals of Pathology and Laboratory Medicine, 5.
 
[12]  Chopra R, Rana R, Zachariah A, Mahajan MK, Prabhakar BR. Epithelioid granulomas in Hodgkin’s disease--prognostic significance. Indian J Pathol Microbiol 1995; 38: 427-33.
 
[13]  Deen J, Banney L, Perry-Keene J. Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. J Cutan Pathol 2017 Dec 11.
 
[14]  Bhatia A, kumar Y, Kathpalia A. Granulomatous inflammation in lymph nodes draining cancer: A coincidence or a significant association. Int J Med and Medical Sci 2009; 1: 013-6