Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review

Nida Saleem^1, , Saima Bashir¹, Syed Nayer Mahmud¹ and Muhammad Haneef¹

¹Nephrology Department, Shifa International Hospital, Islamabad, 00000, Pakistan

Cite this paper

Nida Saleem, Saima Bashir, Syed Nayer Mahmud and Muhammad Haneef. Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review. American Journal of Medical Case Reports. 2021; 9(12):725-729. doi: 10.12691/AJMCR-9-12-17

Abstract

We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

Keywords

Acute interstitial nephritis (AIN), Diabetes, dapagliflozin, SGLT2 inhibitors, acute kidney injury (AKI)

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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