Antidiabetic Activity of Anemarrhena asphodeloides Bge. Polysaccharides

YIN Ai-wu^1, and GAO Peng-fei²

¹Institute of Medical Technology, Xiangtan Medicine and Health Vocational College, China

²School of Pharmacy, Dali University, China

Cite this paper

YIN Ai-wu and GAO Peng-fei. Antidiabetic Activity of Anemarrhena asphodeloides Bge. Polysaccharides. American Journal of Medical Case Reports. 2021; 9(2):116-121. doi: 10.12691/AJMCR-9-2-5

Abstract

The present study was aimed to investigate the anti-diabetic activity of Anemarrhena asphodeloides Bge. Polysaccharides (AAP). Wistar rats were injected with streptozotocin(STZ)to induce diabetes. The APP was prepared at first. After the rats were orally administered for 28 days, related biochemical indicator were determined. AAP was composed of mannose, galacturonic acid, galactose, glucose and xylose in the molar ratio of 12:8.1:2.7:1.3:1 with the average molecular weight of 52.4 kDa. After treatment with AAP (100 and 200 mg·kg^-1) for 28 days there was a significant decrease in blood glucose, SGPT, SGOT, ALP, TC, TG, LDL, BUN and significant increase in body weight, fasting serum insulin, pancreatic insulin and HDL. The activities of SOD and CAT in liver and kidneys also increased. The results of the experiments showed that AAP exerted significant anti-diabetic activity.

Keywords

diabetes mellitus, Anemarrhena asphodeloides Bge, polysaccharides, streptozotocin

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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