Light Chain Cast Nephropathy in an African-American Woman with Waldenström’s Macroglobulinemia

Mohamedanwar Ghandour^1, , Ahmed Abdalrahem², Hammam Shereef³, Yahya Osman-Malik¹ and Hillel Sternlicht¹

¹Department of Internal Medicine- Division of Nephrology, Wayne State University

²Department of internal medicine, Wayne State University

³Department of internal medicine, Beaumont Health System

Cite this paper

Mohamedanwar Ghandour, Ahmed Abdalrahem, Hammam Shereef, Yahya Osman-Malik and Hillel Sternlicht. Light Chain Cast Nephropathy in an African-American Woman with Waldenström’s Macroglobulinemia. American Journal of Medical Case Reports. 2021; 9(3):167-169. doi: 10.12691/AJMCR-9-3-9

Abstract

Waldenström's macroglobulinemia (WM) is a rare cancer of the lymphatic system due to excess IgM monoclonal protein with a rare renal involvement. We describe a case of MW presenting with acute renal failure. A 63-year-old female who was admitted to our hospital for influenza B complicated by acute renal failure during the hospital stay, with creatinine up to 6 mg/dL, despite adequate hydration. Electrophoresis revealed a monoclonal component in the gamma region, which was classified as an IgM k. A kidney biopsy was performed, showing light cast chains suggested the possibility of myeloma kidney. Furthermore, bone marrow histology was performed, revealing lymphoplasmacytic lymphoma. The patient was treated with bortezomib, dexamethasone, and cyclophosphamide, with complete recovery of renal function (creatinine 1.1 mg/dL).

Keywords

Waldenström's macroglobulinemia, light cast chain nephropathy

Copyright

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