Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2021, 9(4), 229-231
DOI: 10.12691/AJMCR-9-4-6
Case Report

A Classical Wide Complex Tachycardia due to Propafenone Toxicity; Uncommon Side Effect of a Commonly Used Medication

Hammam Shereef1, Mohamedanwar Ghandour2, , Sarah Abdelsamad2, Ahmed Subahi3, Ahmed S Yassin3 and Luis Afonso3

1Department of Internal Medicine, Beaumont Hospital-Dearborn, Michigan, USA

2Division of Nephrology, Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA

3Division of Cardiovascular Medicine, Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA

Pub. Date: January 27, 2021
Full Text PDF

Cite this paper

Hammam Shereef, Mohamedanwar Ghandour, Sarah Abdelsamad, Ahmed Subahi, Ahmed S Yassin and Luis Afonso. A Classical Wide Complex Tachycardia due to Propafenone Toxicity; Uncommon Side Effect of a Commonly Used Medication. American Journal of Medical Case Reports. 2021; 9(4):229-231. doi: 10.12691/AJMCR-9-4-6

Abstract

Propafenone is a Class 1 C anti-arrhythmic drug, frequently used in the treatment of supraventricular and ventricular arrhythmias. We herein are presenting a case of 67-year-old female who presented with wide complex tachycardia consistent with Propafenone toxicity and who responded immediately to sodium bicarbonate injections. This case shines the light on a common effect of Propafenone toxicity and aims to increase the clinician awareness about such a documented reaction, that can be reversed by a simple treatment like sodium bicarbonate.

Keywords

propafenone, tachycardia, atrial fibrillation

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Konety SH, Olshansky B . The "pill-in-the-pocket" approach to atrial fibrillation. N Engl J Med 2005; 352: 1150-1.
 
[2]  Elsa-Grace Giardina. Major side effects of class I antiarrhythmic drugs. Uptodate updated on Jun 13, 2019.
 
[3]  Amerini S, Bernabei R , Carbonin P , et al . Electrophysiological mechanism for the antiarrhythmic action of propafenone: a comparison with mexiletine. Br J Pharmacol 1988; 95: 1039-46.
 
[4]  De Soyza N, Terry L, Murphy ML. Effect of propafenone in patients with stable ventricular arrhythmias. Am Heart J 1984; 108: 285-9.
 
[5]  Safety and tolerability of long-term propafenone therapy for supraventricular tachyarrhythmias. The Propafenone Multicenter Study Group. Podrid PJ1, Anderson JL. Am J Cardiol. 1996 Aug 15; 78(4): 430-434.
 
[6]  Bayram Z, Güner A, Doğan C, Yılmaz F, Özdemir N. Severe cardiac toxicity following alcohol intake in a patient using therapeutic dose of Propafenone. Turk Kardiyol Dern Ars. 2017 Dec; 45(8): 752-754.
 
[7]  Griffin JP, D’Arcy PF. A Manual of Adverse Drug Interactions. 5th edn. Amsterdam: Elselvier Science BV; 1997.
 
[8]  Zel jković I, Bulj N, Kolačević M, Čabrilo V, Brkljačić DD, Manola Š. Failure of Intracardiac Pacing After Fatal Propafenone Overdose: A Case Report. J Emerg Med. 2018 Apr; 54(4): e65-e68.