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American Journal of Medical Case Reports. 2021, 9(6), 321-324
DOI: 10.12691/AJMCR-9-6-4
Original Research

Kikuchi Fujimoto Disease: An Unusual Association with Bicytopenia Mimicking Lymphoma

Ahmed Hashim1, , Mohamedanwar Ghandour2, Hammam Shereef1, Ahmed H Abdulrahim3, Rabia Bangash1, Faisal Musa4 and Fadi Abu Yasin5

1Department of Internal Medicine, Beaumont Health- Dearborn, MI, USA

2Division of Nephrology, Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, MI, USA

3Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, MI, USA

4Division of Oncology, Department of Internal Medicine, Beaumont Health- Dearborn, MI, USA

5Division of Infectious Diseases, Department of Internal Medicine, Beaumont Health- Dearborn, MI, USA

Pub. Date: March 18, 2021
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Cite this paper

Ahmed Hashim, Mohamedanwar Ghandour, Hammam Shereef, Ahmed H Abdulrahim, Rabia Bangash, Faisal Musa and Fadi Abu Yasin. Kikuchi Fujimoto Disease: An Unusual Association with Bicytopenia Mimicking Lymphoma. American Journal of Medical Case Reports. 2021; 9(6):321-324. doi: 10.12691/AJMCR-9-6-4

Abstract

We report a case of Kikuchi-Fujimoto disease (KFD) in an 18-year-old African American female who presents with a high-grade fever, sweating, and painful right-sided cervical lymphadenopathy. Lab analysis showed leukopenia, thrombocytopenia, and an elevated C-reactive protein. The remaining infectious and autoimmune work-up was negative. Given her clinical presentation, an infectious etiology was suspected, and broad-spectrum antibiotics were empirically started. Bicytopenia in the setting of lymphadenopathy raised the suspicion for lymphoma with bone marrow infiltration. An excisional biopsy was performed, and a histological exam of the lymph nodes showed necrotizing histiocytic lymphadenitis consistent with KFD. She was discharged on Naproxen and Tylenol with a referral to Rheumatology. This case highlights the rarity of bicytopenia in KFD and the importance of early and prompt diagnosis in order to avoid unnecessary testing and inappropriate treatment.

Keywords

Kikuchi-Fujimoto Disease, lymphadenopathy

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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