American Journal of Medical Case Reports. 2021, 9(8), 397-401
DOI: 10.12691/AJMCR-9-8-4
A Case of Paraneoplastic Arthralgias
David Pisarcik1, , Gabriel Kousourou2 and Nagadarshini Vinod2
1Department of Medicine, Indiana University, Indianapolis, IN, USA
2Department of Rheumatology, Indiana University, Indianapolis, IN, USA
Pub. Date: April 25, 2021
Cite this paper
David Pisarcik, Gabriel Kousourou and Nagadarshini Vinod. A Case of Paraneoplastic Arthralgias.
American Journal of Medical Case Reports. 2021; 9(8):397-401. doi: 10.12691/AJMCR-9-8-4
Abstract
Hypertrophic Osteoarthropathy (HOA) is a rare condition that presents with arthralgias, digital clubbing, and abnormal periosteal bone deposition seen on x rays. The secondary form of HOA may be associated with an underlying malignancy, thus highlighting the importance of early clinical recognition. We present the case of a 44-year-old woman who presented with several weeks of lower extremity swelling, arthralgias, and digital clubbing who was later found to have non-small cell lung cancer. Diagnosis can be challenging due to variable presentations that can often mimic other forms of inflammatory arthritis. Treatment is focused on addressing the underlying cause. Nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used for pain relief while intravenous bisphosphonates have been trialed with some success in case reports.
Keywords
paraneoplastic syndrome, arthralgias, clubbing, periostosis, hypertrophic osteoarthropathy
Copyright
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References
[1] | MATINEZ-LAVIN, M., et al. “Hypertrophic osteoarthropathy: consensus on its definition, classification, assessment and diagnostic criteria.” Journal of rheumatology. 20.8 (1993): 1386-1387. |
|
[2] | Zhang, Zeng, Changqing Zhang, and Zhenlin Zhang. “Primary hypertrophic osteoarthropathy: an update.” Frontiers of medicine 7.1 (2013): 60-64. |
|
[3] | Yap, Felix Y., et al. “Hypertrophic osteoarthropathy: clinical and imaging features.” Radiographics. 37.1 (2017): 157-195. |
|
[4] | Meyer, Hans-Jonas, et al. “Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors.” Medicine. 96.36 (2017). |
|
[5] | Harada, Shun-ichi, et al. “Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.” The Journal of clinical investigation. 93.6 (1994): 2490-2496. |
|
[6] | Bozzao, Francesco, et al. “Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.” BMC musculoskeletal disorders. 19.1 (2018): 1-6. |
|
[7] | Ulutaş, Firdevs, et al. “Hypertrophic Osteoarthropathy Presenting as Rheumatoid Arthritis Mimicker: A Case Report.” Cureus. 12.7 (2020). |
|
[8] | Parada-Turska, Jolanta. “Paraneoplastic rheumatologic syndromes in the elderly.” Wiadomosci Lekarskie (Warsaw, Poland: 1960). 72.9 cz 1 (2019): 1646-1654. |
|
[9] | Pineda, Carlos, and Manuel Martínez-Lavín. “Hypertrophic osteoarthropathy: what a rheumatologist should know about this uncommon condition.” Rheumatic diseases clinics of North America. 39.2 (2013): 383-400. |
|
[10] | Mudalsha, Ravina, et al. “Tc-99m MDP bone scintigraphy in a case of Touraine-Solente-Gole syndrome.” Indian journal of nuclear medicine: IJNM: the official journal of the Society of Nuclear Medicine, India. 26.1 (2011): 46. |
|
[11] | Ito, Takeo, et al. “Hypertrophic pulmonary osteoarthropathy as a paraneoplastic manifestation of lung cancer.” Journal of thoracic oncology. 5.7 (2010): 976-980. |
|