Skip Navigation Links.
Collapse <span class="m110 colortj mt20 fontw700">Volume 12 (2024)</span>Volume 12 (2024)
Collapse <span class="m110 colortj mt20 fontw700">Volume 11 (2023)</span>Volume 11 (2023)
Collapse <span class="m110 colortj mt20 fontw700">Volume 10 (2022)</span>Volume 10 (2022)
Collapse <span class="m110 colortj mt20 fontw700">Volume 9 (2021)</span>Volume 9 (2021)
Collapse <span class="m110 colortj mt20 fontw700">Volume 8 (2020)</span>Volume 8 (2020)
Collapse <span class="m110 colortj mt20 fontw700">Volume 7 (2019)</span>Volume 7 (2019)
Collapse <span class="m110 colortj mt20 fontw700">Volume 6 (2018)</span>Volume 6 (2018)
Collapse <span class="m110 colortj mt20 fontw700">Volume 5 (2017)</span>Volume 5 (2017)
Collapse <span class="m110 colortj mt20 fontw700">Volume 4 (2016)</span>Volume 4 (2016)
Collapse <span class="m110 colortj mt20 fontw700">Volume 3 (2015)</span>Volume 3 (2015)
Collapse <span class="m110 colortj mt20 fontw700">Volume 2 (2014)</span>Volume 2 (2014)
Collapse <span class="m110 colortj mt20 fontw700">Volume 1 (2013)</span>Volume 1 (2013)
American Journal of Medical Case Reports. 2021, 9(9), 451-455
DOI: 10.12691/AJMCR-9-9-4
Case Report

New Onset Aplastic Anemia after a COVID-19 Infection: A Case Report

Vikram Sumbly1, , Raheel Siddiqui1, Mohsen Alshamam1, Tamara Kurbanova1 and Vincent Rizzo1

1Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Jamaica, United States

Pub. Date: May 20, 2021
Full Text PDF

Cite this paper

Vikram Sumbly, Raheel Siddiqui, Mohsen Alshamam, Tamara Kurbanova and Vincent Rizzo. New Onset Aplastic Anemia after a COVID-19 Infection: A Case Report. American Journal of Medical Case Reports. 2021; 9(9):451-455. doi: 10.12691/AJMCR-9-9-4

Abstract

Aplastic anemia (AA) is a potentially life-threatening acquired bone marrow failure syndrome which leads to central pancytopenia. Although the exact pathogenesis of this disorder is yet to be fully understood, it is thought to be primarily caused by auto-immunity. Unlike other viruses, the association between SARS CoV-2 and AA remains insufficiently explored in current literature. Based on the few cases of COVID-19-induced central pancytopenia and the available literature on virus-induced AA, we propose that the development of AA in COVID-19 patients may be attributable to SARS CoV-2. We report the case of a 29-year-old female that developed AA after being hospitalized for COVID-19. She had a favorable clinical outcome after several courses of immunosuppressive therapy.

Keywords

Aplastic anemia, COVID-19, bone marrow transplant, immunosuppressive therapy

Copyright

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]  Miano M, Dufour C. The diagnosis and treatment of aplastic anemia: a review. Int J Hematol. Jun 2015; 101(6): 527-35.
 
[2]  Rauff B, Idrees M, Shah SA, et al. Hepatitis associated aplastic anemia: a review. Virol J. Feb 28 2011; 8: 87.
 
[3]  Kurtzman G, Young N. 4 Viruses and bone marrow failure. Baillière's Clinical Haematology. 1989/01/01/1989; 2(1): 51-67.
 
[4]  Zhao Y, He J, Wang J, et al. Development of pancytopenia in a patient with COVID-19. J Med Virol. Mar 2021; 93(3): 1219-1220.
 
[5]  Young NS. Aplastic Anemia. N Engl J Med. Oct 25 2018; 379(17): 1643-1656.
 
[6]  King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. Sep 9 2011; 11(10): 685-92.
 
[7]  Fara A, Mitrev Z, Rosalia RA, Assas BM. Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open Biol. Sep 2020; 10(9): 200160.
 
[8]  Morinet F, Leruez-Ville M, Pillet S, Fichelson S. Concise Review: Anemia Caused by Viruses. STEM CELLS. 2011; 29(11): 1656-1660.
 
[9]  Velier M, Priet S, Appay R, et al. Severe and Irreversible Pancytopenia Associated With SARS-CoV-2 Bone Marrow Infection in a Patient With Waldenstrom Macroglobulinemia. Clinical Lymphoma Myeloma and Leukemia. 2021/01/13/ 2021.
 
[10]  Hernandez JM, Quarles R, Lakshmi S, et al. Pancytopenia and Profound Neutropenia as a Sequela of Severe SARS-CoV-2 Infection (COVID-19) With Concern for Bone Marrow Involvement. Open Forum Infectious Diseases. 2021; 8(2).
 
[11]  Mariani R, Liu H. Severe transient pancytopenia with dyserythropoiesis and dysmegakaryopoiesis in COVID-19-associated MIS-C. Blood. 2020; 136(25): 2964-2964.
 
[12]  Issa N, Lacassin F, Camou F. First case of persistent pancytopenia associated with SARS-CoV-2 bone marrow infiltration in an immunocompromised patient. Annals of Oncology. 2020/10/01/ 2020; 31(10): 1418-1419.